The development of nonenzymatic glucose sensors with favorable electrocatalytic activity and chemical stability is crucial in various fields. Therefore, in this study, we systematically investigate a series of ZIF-Zn_xCo_1–x materials (0 ≤ x ≤ 1) and demonstrate that the appropriate combination of Zn²⁺ and Co²⁺ within a metal–organic framework (MOF) delivers a promising platform for developing a glucose sensor with good glucose sensitivity and superior chemical stability. Herein, ZIF-Zn_0.5Co_0.5 was selected as the optimal glucose-sensing material owing to its high Co²⁺ content and well-preserved crystallinity and porosity after base treatment for 14 days. Remarkably, ZIF-Zn_0.5Co_0.5 showed superior electrocatalytic glucose-sensing performance compared to ZIF-67(Co) owing to its excellent chemical stability. The observed glucose-sensing performance was comparable to those of benchmark cobalt-based electrocatalysts. Furthermore, ZIF-Zn_0.5Co_0.5 exhibited excellent selectivity for glucose over possible interfering species, as well as reusability and electrochemical stability, thereby suggesting its potential applicability for nonenzymatic glucose sensing.

DOI: https://doi.org/10.1021/acssuschemeng.2c04306